Elucidating the role of mammalian CLPP in mitochondrial translation regulation
The team led by Prof. Aleksandra Trifunovic is investigating the function of mitochondria in the development of disease and during aging. When mitochondria experience stress or when dysfunction occurs, they send signals to the cell nucleus, which launches different types of adaptive cell responses. Transcription factors are activated and stimulate the expression of specific sets of genes, whose products enable the cell to adapt to the changes. The scientists aim to understand this signaling cascade in detail.
Szczepanowska K, Maiti P, Kukat A, Hofetz E, Nolte H, Senft K, Becker C, Ruzzenente B, Hornig-Do HT, Wibom R, Wiesner RJ, Krüger M and Trifunovic A (2016) CLPP coordinates mitoribosomal assembly through the regulation of ERAL1 levels. EMBO J (in press).
Seiferling D, Szczepanowska K, Becker C, Senft K, Hermans S, Maiti P, Kukat A and Trifunovic A (2016) Loss of ClpP alleviates mitochondrial cardiomyopathy without affecting the mammalian UPRmt”. EMBO Rep. 17(7):953-64. doi: 10.15252/embr.201642077.
Dogan SA, Pujol C, Maiti P, Kukat A, Wang S, Hermans S, Senft K, Wibom R, Rugarli EI, Trifunovic A (2014) Tissue-specific loss of DARS2 activates stress responses independently of respiratory chain deficiency in the heart. Cell Metab 19: 458-469